From plant-based formulas to dermatologist-recommended classics, here are some of the top-rated eczema creams and lotions available without a prescription—each selected to help restore comfort, moisture, and calm to your skin.
Managing eczema isn’t always easy. The itchiness, dryness, and irritation can seriously impact your day-to-day life—especially when flare-ups strike without warning. For many, finding a reliable over-the-counter (OTC) solution can bring much-needed relief. That’s why we’ve curated this list of the best creams and lotions for eczema—solutions that are gentle, effective, and often packed with skin-nourishing ingredients. Whether you're dealing with eczema on your hands, face, or body, the right lotion can make all the difference.
What Ingredients are Most Effective for My Eczema?
Oat or Shea Butter
These rich moisturizers create a barrier to help prevent water loss and soothe irritated skin.
Vitamin E Oil
A powerful antioxidant that calms inflammation and supports skin repair.
Aloe
Hydrates and cools skin while reducing redness and irritation.
Hypoallergenic
Free from common irritants, making these formulas safer for sensitive skin types.
Minimalist Formulas
Less is more—fewer ingredients mean fewer potential triggers for flare-ups.
Barrier Support
Look for ceramides or similar agents that reinforce the skin’s natural protective layer.
Top 5 Eczema Lotions & Creams Found Over-The-Counter
1. Acure Everyday Eczema Lotion
A clean, effective solution made with 2% colloidal oatmeal and soothing lavender. The Acure Everyday Eczema Lotion is plant-based, cruelty-free, vegan, and made without harsh chemicals. Its dermatologist-tested formula calms dry, itchy skin and supports your skin barrier—plus, it comes in eco-conscious packaging.
How to Use: Apply liberally to affected areas as needed.
2. Bioderma Atoderm Intensive Balm
An ultra-nourishing balm that restores the skin barrier and alleviates itchiness. Ideal for very dry, irritated skin.
Key Features: Fragrance-free, paraben-free, hypoallergenic.
How to Use: Apply once or twice daily to clean, dry skin.
3. Aveeno Eczema Therapy Daily Moisturizing Cream
Formulated with colloidal oatmeal to help calm itchy skin and restore moisture.
Key Features: Steroid-free, fragrance-free, and clinically proven to reduce eczema symptoms.
How to Use: Apply generously to affected areas as needed.
4. Vaseline Eczema Calming Therapy Cream
Provides lasting relief and creates a protective barrier to prevent further irritation.
Key Features: Contains colloidal oatmeal and ceramides; designed to soothe dry, itchy, and inflamed skin.
How to Use: Apply as often as needed.
5. Eczema Honey Original Skin-Soothing Cream
Made with natural ingredients like honey and beeswax, this cream helps relieve itchiness while locking in hydration.
Key Features: Gentle and natural formula with honey, beeswax, and nourishing oils.
How to Use: Smooth a thin layer onto the skin whenever relief is needed.
Tips to Apply Eczema Creams and Lotions for Best Results
- Apply immediately after bathing to lock in moisture.
- Pat skin dry—don’t rub.
- Use liberally and frequently, especially after washing hands.
- Consider applying a thicker layer before bed.
- For severe cases, speak to a dermatologist about wet wrap therapy.
Give Your Skin the Relief It Needs!
When it comes to managing eczema, the best creams and lotions for eczema are the ones that truly work for your skin. Whether you’re looking for a plant-based formula, something hypoallergenic, or a dermatologist favorite, there are effective OTC options to help you find comfort and calm.
At Acure, we believe in science-backed skincare that delivers visible results without compromise. Explore our clean, natural lotion for eczema and discover the difference a thoughtful, effective formula can make.
